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KMID : 0389420090170030277
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Korean Journal of Stress Research
2009 Volume.17 No. 3 p.277 ~ p.284
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Time Course of the Effects of Nitric Oxide on Voluntary Wheel Running Behavior following Restraint Stress
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Park Chan
Kang Hye-Min
Jin Ji-Zi
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Abstract
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The involvement of nitric oxide (NO) in stress-induced motivational behavior change in mice was evaluated using voluntary wheel running in the cage. The effects of daily restraint stress on voluntary running were followed for two weeks. Daily restraint stress for 3 hours reduced voluntary running from Day 1 to Day 7. The effects of the NO precursor, L-arginine, and the NO synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on voluntary running were also observed for two weeks. In the L-NAME-treated group, voluntary running decreased on Days 1 to 3 compared to the baseline level (Day 0; voluntary running levels before stress). Treatment with L-arginine following restraint stress markedly sustained the voluntary running activity to basal level, whereas treatment with L-NAME following restraint stress prolonged the decrease in voluntary running induced by stress. These results suggest that NO may protect against stress-induced motivational behavioral change.
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KEYWORD
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Restraint stress, Voluntary wheel running, Nitric oxide
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